A study published online in the journal JAMA Network Open found that MRI scans performed on healthy newborns. At the same time, they slept indicated that babies facing social disadvantages such as poverty tended to be born with smaller brains than babies whose mothers had higher household incomes.
The European Commission issued formal objections Friday to Bayer’s planned $66 billion takeover of Monsanto, according to two people briefed on the case, signaling the deal may be blocked unless the German company makes more significant concessions.
The objections from Brussels represent a stark ultimatum for the agrichemical giant, which has spent at least 12 months trying to bring around EU regulators on the politically charged mega-merger.
When announced, Bayer’s tie-up with Monsanto was set to create the world’s largest portfolio of pesticides, but Bayer has already sold off some businesses to allay competition concerns. Monsanto is a bête noire among European environmentalists because of its production of genetically modified crops and the ubiquitous pesticide glyphosate, and many nongovernmental organizations are pinning their hopes on European Commissioner for Competition Margrethe Vestager to kill off what has been dubbed by some as the #mergerfromhell.
Given her track record on other tie-ups in the sector, however, it is more likely that she will simply press for divestments. Bayer and Monsanto’s merger is the last of the trio of mega-mergers that have dramatically consolidated the agrichemical industry. Two of the deals — Dow’s tie-up with DuPont and ChemChina’s acquisition of Syngenta — obtained EU clearance at the end of long probes and on the condition they sold off some businesses.
Many nongovernmental organizations are pinning their hopes on Vestager to kill off what has been dubbed by some as the #mergerfromhell | Olivier Hoslet/EPA
The Commission, which has until March 5 to reach a final decision, has the power to either block mergers or demand divestments by the companies.
As was the case with the inquiry into Dow and DuPont, which merged earlier this year, people following the Bayer case say the Commission is running an extremely wide-reaching investigation and is demanding huge amounts of information.
The objections were issued Friday, according to one of the people briefed. The Commission’s specific concerns remain confidential. The Commission and Monsanto declined to comment.
“We do not comment on rumors,” said Utz Klages, a spokesperson for Bayer.
Bayer already moved to resolve some of Vestager’s main concerns after she opened an in-depth probe into the deal in August. Investigators warned then that Leverkusen, Germany-based Bayer was one of only a few companies to produce a genuine alternative to Missouri-based Monsanto’s blockbuster herbicide Roundup, based on the controversial herbicide glyphosate. Bayer announced in October that it was selling the product in question — glufosinate-ammonium — to BASF, along with various seeds activities, for €5.9 billion.
It’s not clear if regulators were involved in drawing up that deal.
The Commission objections come less than a month after the EU gave a fresh bill of health to Roundup.
Bayer also has tried to allay investigators’ concerns that the merger would create the strongest global market force in seeds and traits. In addition to being able to raise prices, the merged firm would have less incentive to invest in developing such products, they said. In addition, investigators are examining how the advent of digital agriculture and the use of big data analyses could reinforce the strong market position a merged Bayer-Monsanto would have.
The Bayer-Monsanto deal has sparked intense opposition in Europe and further afield, with hundreds of thousands of petitioners calling on the Danish commissioner to block it, amid concerns it will put huge levels of power in both the seed and pesticide market in the hands of a single player.
Much of the public furor about glyphosate, however, lies well beyond the scope of Vestager’s investigation.
“The other concerns you raise are handled by my colleagues and national authorities and are subject to European and national rules to protect food safety, consumers, the environment and the climate,” Vestager wrote in August, in a letter sent to petitioners.
She said she had received more than 50,000 petition emails and more than 5,000 postcards and letters on the case.
The Commission objections come less than a month after the EU gave a fresh bill of health to Roundup, which was renewed for another five years.
That decision triggered uproar among environmentalists and health groups, which claimed the substance not only caused cancer but endangered soil quality and biodiversity. While the World Health Organization’s International Agency for Research on Cancer concluded that glyphosate “probably” causes cancer, two EU agencies determined that it was safe.
The post Vestager ramps up pressure on Bayer-Monsanto mega-merger appeared first on News Wire Now.
Monkeypox: First deaths outside Africa in Brazil and Spain
Brazil and Spain have reported their first monkeypox deaths.
A 41-year-old man in Brazil became the first fatality from the virus outside Africa. Spain announced two deaths soon afterwards – the first in Europe.
Last week, the World Health Organization (WHO) declared the monkeypox outbreak a global health emergency.
But infections are usually mild and the risk to the general population is low.
On Friday Brazil’s health ministry said the victim there had suffered from lymphoma and a weakened immune system, and “comorbidities aggravated his condition”.
Brazil has so far reported 1,066 confirmed cases and 513 suspected cases of the virus. Data from Brazil’s health ministry indicates that more than 98% of confirmed cases were in men who have sex with men.
Shortly afterwards, Spain’s health ministry confirmed Europe’s first death from the virus – a patient who suffered from encephalitis.
A second death linked to monkeypox was confirmed by Spanish authorities on Saturday.
The health ministry said that of 3,750 monkeypox patients with available information, 120 or 3.2% had been hospitalised.
According to the US Centers for Disease Control and Prevention, there are 21,148 cases worldwide.
The monkeypox virus is a member of the same family of viruses as smallpox, although it is much less severe and experts say chances of infection are low.
It occurs mostly in remote parts of central and west African countries, near tropical rainforests.
Health officials are recommending people at highest risk of exposure to the virus – including some gay and bisexual men, as well as some healthcare workers – should be offered a vaccine.
Last week, WHO director general Dr Tedros Adhanom Ghebreyesus said declaring the outbreak a global health emergency would help speed up the development of vaccines and the implementation of measures to limit the spread of the virus.
Dr Tedros said the risk of monkeypox is moderate globally, but high in Europe.
But, he added, “this is an outbreak that can be stopped with the right strategies in the right groups”. The WHO is issuing recommendations, which it hopes will spur countries to take action to stop transmission of the virus and protect those most at risk.
Read from: https://www.bbc.com/news/health-62350022
Covid: Woman caught virus twice within record 20 days
A 31-year-old healthcare worker caught Covid twice within 20 days – the shortest-known gap between infections, Spanish researchers have claimed.
Tests show the woman was infected with two different variants – Delta in late December and then Omicron in January.
This shows that even if you have had Covid before, you can still be infected again even if fully vaccinated, the researchers say.
Reinfections in the UK require 90 days between positive tests.
Based on that definition, health officials say nearly 900,000 people have potentially been infected twice with Covid up to the start of April.
It is difficult to pin down an exact number, because only whole genome sequencing can confirm the infections are caused by different strains, and very few positive tests go through this process.
The Spaniard did not develop any symptoms after her first positive PCR test, but less than three weeks later she developed a cough and fever which prompted her to take another test.
When the tests were analysed further, they showed the patient had been infected by two different strains of coronavirus.
In a presentation at the European Congress of Clinical Microbiology and Infectious Diseases, study author Dr. Gemma Recio said the case highlighted that Omicron can “evade the previous immunity acquired either from a natural infection with other variants or from vaccines”.
She said: “In other words, people who have had Covid-19 cannot assume they are protected against reinfection, even if they have been fully vaccinated.
“Nevertheless, both previous infection with other variants and vaccination do seem to partially protect against severe disease and hospitalisation in those with Omicron,” added Dr Recio, from the Institut Catala de Salut, Tarragona in Spain.
She said monitoring reinfections in people who were fully vaccinated was important, and would help the search for variants which evade vaccines.
Covid reinfections rose sharply in December 2021 after the much more infectious Omicron variant emerged, and there was another increase when a slightly different version of it, called BA.2, appeared in early March.
Before that, 1% of all cases recorded in the UK were labelled as second infection – but that has now gone up to 11%.
Most are likely to be people infected by the Alpha or Delta variants and then infected again by the more contagious Omicron.
Scientists predict that eventually everyone will catch Covid twice, and probably many more times over the course of their lifetime.
Read from: https://www.bbc.com/news/health-61161529
Poverty, crime linked to differences in newborns’ brains
MRI scans of full-term newborns born to mothers living in poverty revealed smaller volumes across the entire brain — including the cortical grey matter, subcortical grey matter and white matter — than found in the brains of babies whose mothers had higher household incomes.
The brain scans, conducted only a few days to weeks after birth, also showed more miniature folding of the brain among infants born to mothers living in poverty. Fewer and shallower folds typically signify brain immaturity. The healthy human brain folds as it grows and develops, providing the cerebral cortex with a more extensive functional surface area.
A second study of data from the same sample of 399 mothers and their babies — this one published online in the journal Biological Psychiatry — reports that pregnant mothers from neighbourhoods with high crime rates gave birth to infants whose brains functioned differently during their first weeks of life than babies born to mothers living in safer neighbourhoods.
Functional MRI scans of babies whose mothers were exposed to crime displayed weaker connections between brain structures that process emotions and structures that help regulate and control those emotions. Maternal stress is believed to be one of the reasons for the weaker connections in the babies’ brains.
“These studies demonstrate that a mother’s experiences during pregnancy can have a major impact on her infant’s brain development,” said Christopher D. Smyser, MD, one of the principal investigators. “Like that old song about how the ‘knee bone is connected to the shin bone,’ there’s a saying about the brain that ‘areas that fire together wire together.’ We’re analysing how brain regions develop and form early functional networks because how those structures develop and work together may impact long-term development and behaviour.”
Babies in the study were born from 2017 through 2020, before the COVID-19 pandemic. Smyser, a professor of neurology, paediatrics and radiology, said that babies are fed when they arrive for scans because they tend to fall asleep after eating to scan newborns during the first few weeks of life successfully. They are then snugly swaddled into blankets and a device that helps keep them comfortable and still. The brain scans take place while they sleep.
In the study involving the effects of poverty, the researchers focused on 280 mothers and their newborns. First author Regina L. Triplett, MD, a postdoctoral fellow in neurology, had expected to find that maternal poverty — referred to in the paper as a social disadvantage — could affect the babies’ developing brains. But she also expected to see the effects of psychosocial stress, which includes measures of adverse life experiences and anxiety and depression.
affected the brain across many of its structures, but there were no significant effects related to psychosocial stress,” Triplett said. “Our concern is that as babies begin life with these smaller brain structures, their brains may not develop as healthy as the brains of babies whose mothers lived in higher-income households.”
In the second study, which implicated living in high-crime neighbourhoods as a factor in weaker functional connections in the brains of newborns, first author Rebecca G. Brady, a graduate student in the university’s Medical Scientist Training Program, found that unlike the effects of poverty, the results of exposure to crime were focused on particular areas of the babies’ brains.
“Instead of a brain-wide effect, living in a high-crime area during pregnancy seems to have more specific effects on the emotion-processing regions of babies’ brains,” Brady said. “We found that this weakening of the functional connections between emotion-processing structures in the babies’ brains was robust when we controlled for other types of adversity, such as poverty. It appears that stresses linked to crime had more specific effects on brain function.”
Reducing poverty and lowering crime rates are well-established goals in public policy and health. And the researchers believe protecting expectant mothers from crime and helping them out of poverty will do more than improve brain growth and connections in their babies. But if social programs that aim to help people reach their full potential are to succeed, the researchers said the policies must focus on assisting people even before they are born.
“Several research projects around the country are now providing money for living expenses to pregnant mothers. Some cities have determined that raising pregnant mothers out of poverty is good public policy,” Smyser said. “The evidence we’re gathering from these studies certainly would support that idea.”
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